横山 顕

横山 顕Akira Yokoyama

  • 久里浜医療センター 臨床研究部部長
  • 慶應義塾大学医学部 内科客員講師

専門領域

  • アルコールによる臓器障害
  • アルコール依存症の治療

認定資格

  • 医学博士
    【受賞歴】
  • 平成7年度 慶應義塾大学医学部三四会「三四会賞」受賞
    「内視鏡的ヨード染色を用いたアルコール依存症における早期食道癌スクリーニングの成功」
  • 平成10年度 慶應義塾大学医学振興財団「特別奨励研究」受賞
    「アルコール代謝と発癌に関する研究」
  • 平成21年度 慶應義塾大学医学部三四会「北島賞」受賞
    「飲酒関連食道・頭頸部癌の危険因子と予防に関する研究」

所属学会、委員会、役職等

  • 日本アルコール・アディクション医学会
  • 日本癌学会
  • 日本消化器内視鏡学会
  • 平成13年より  慶應義塾大学医学部 内科客員講師
  • 平成12年-15年 厚労省がん助成金研究(12-12)主任研究者
  • 平成19年 Member of the WHO IARC Monograph Working Group('Alcoholic beverage consumption, acetaldehyde and urethane', Lyon, France, 6 - 13 February 2007)

主な論文、著作リスト

  • Yokoyama A, Omori T, Tokoyama T. Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and Screening for Cancer in the upper aerodigestive tract in East Asians. Keio J Med 59; 115-130, 2011.
  • Aida J, Yokoyama A, Izumiyama N, Nakamura K, Ishikawa N, Poon SS, Fujiwara M, Sawabe M, Matsuura M, Tomio A, Takubo K. Alcoholics show reduced telomere length in the oesophagus. J Pathol 223; 410-416, 2011.
  • Yokoyama A, Tsustsumi E, Imazeki H, Suwa Y, Nakamura C, Yokoyama T. Polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men. Alcohol Clin Exp Res 34; 1246-1256, 2010
  • Yang SJ, Yokoyama A, Yokoyama T, Huang YC, Wu SY, Shao Y, Niu J, Wang J, Lui Y, Zhou XQ, Yang CX. Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: A meta-analysis. World J Gastroenterol 16; 4210-4220, 2010
  • Yokoyama A, Yokoyama T, Omori T. Past and current tendency for facial flushing after a small dose of alcohol is a marker for increased risk of upper aerodigestive tract cancer. Cancer Sci 101; 2497-2498, 2010
  • Yokoyama A, Kumagai Y, Yokoyama T, Omori T, Kato H, Igaki H, Tsujinaka T, Muto M, Yokoyama M, Watanabe H. Health risk appraisal models for mass screeningfor esophageal and pharyngeal cancer: an endoscopic follow-up study of cancer-free Japanese men. Cancer Epidemiol Biomarkers Prev 18: 651-655, 2009
  • Boccia S, Hashibe M, Galli P, De Feo E, Asakage T, Hashimoto T, Hiraki A, Katoh T, Nomura T, Yokoyama A, van Duijn CM, Ricciardi G, Boffetta P. Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendlian randomization approach. Cancer Epidemiol Biomarkers Prev 18: 248-254, 2009
  • Brooks PJ, Enoch MA, Doldman D, Li TK, Yokoyama A. The alcohol flushing response: an unrecognized risk factor of esophageal cancer from alcohol consumption, PLoS Med 6: e50, 258-263, 2009
  • Yokoyama A, Omori T, Yokoyama T, Kawakubo H, Mori S, Matsui T, Maruyama K. Chronic atrophic gastritis and metachrnous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma. Alcohol Clin Exp Res 33: 898-905, 2009
  • Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Mizukami T, Yokoyama T. Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. Alcohol Clin Exp Res 32: 1607-1614, 2008
  • Yokoyama A, Omori T, Yokoyama T, Sato Y, Kawakubo H, Maruyama K. Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: A long-term endoscopic follow-up study. Cancer Sci 99: 1164-1171, 2008
  • Yokoyama T, Yokoyama A, Kumagai Y, Omori T, Kato H, Igaki H, Tsujinaka T, Muto M, Yokoyama M, Watanabe H. Health Risk Appraisal Models for Mass Screening of Esophageal Cancer in Japanese Men. Cancer Epidemiol Biomarkers Prev 17: 2846-2854, 2008
  • Shimizu Y, Omori T, Yokoyama A, Yoshida T, Hirota J, Ono Y, Yamamoto J, Kato M, Asaka M. Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine staining: high-grade intra-epithelial neoplasia turns pink within a few minutes. J Gastroenterol Hepatol 23: 546-550, 2008
  • Yokoyama A, Omori T, Tanaka Y, Yokoyama T, Sugiura H, Mizukami T, Matsushita S, Higuchi S, Maruyama K, Ishii H, Hibi T. p53 protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma. Cancer Lett 247: 243-252, 2007
  • Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Yokoyama T. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. Int J Cancer 121: 1047-1054, 2007
  • Yokoyama A, Yokoyama T, Omori T, Matsushita S, Mizukami T, Takahashi H, Higuchi S, Maruyama K, Ishii H, Hibi T. Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis, and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men. J Gastroenterol Hepatol 22: 210-217, 2007
  • Asakage T, Yokoyama A, Haneda T, Yamazaki M, Muto M, Yokoyama T, Kato H, Igaki H, Tsujinaka T, Kumagai Y, Yokoyama M, Omori T, Watanabe H. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and drinking, smoking, and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. Carcinogenesis 28: 865-874, 2007

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