専門領域

• アルコールによる臓器障害
• アルコール依存症の治療

認定資格

• 医学博士

【受賞歴】
• 平成7年度　慶應義塾大学医学部三四会「三四会賞」受賞
  「内視鏡的ヨード染色を用いたアルコール依存症における早期食道癌スクリーニングの成功」
• 平成10年度　慶應義塾大学医学振興財団「特別奨励研究」受賞
  「アルコール代謝と発癌に関する研究」
• 平成21年度　慶應義塾大学医学部三四会「北島賞」受賞
  「飲酒関連食道・頭頸部癌の危険因子と予防に関する研究」

所属学会、委員会、役職等

• 日本アルコール・アディクション医学会
• 日本癌学会
• 日本消化器内視鏡学会
• 平成13年より　 慶應義塾大学医学部　内科客員講師
• 平成12年-15年　厚労省がん助成金研究(12-12)主任研究者
• 平成19年　Member of the WHO IARC Monograph Working Group（'Alcoholic beverage consumption, acetaldehyde and urethane', Lyon, France, 6 - 13 February 2007）

主な論文、著作リスト

• Yokoyama A,Yokoyama T,Omori T,et al : Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women. PLoS One. 2019 Jan 14(1):e0210546.
• Yokoyama A,Taniki N,Hara S,et al : Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence. J Gastroenterol. 2018 53(5):660-669.
• 横山顕 : 食道扁平上皮癌の危険因子と頭頚部・胃を含む field cancerization. 日本消化器病学会雑誌 2018 115:868-80.
• 横山顕 : (著書) お酒を飲んで、がんになる人、ならない人. 星和書店. 2017
• Yokoyama A,Hirata K,Nakamura R,et al : Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men. World J Gastroenterol. 2017 Oct 21;23(39):7150-7159.
• Yokoyama A,Katada C,Yokoyama T,et al : Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. PLoS One. 2017 Apr 12(4):e0175182.
• Hirata K,Yokoyama A,Nakamura R,et al. : Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men. Cancer Sci. 2017 108(5):1058-1064.
• Yokoyama A,Brooks PJ,Yokoyama T,et al. : Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2. Jpn J Clin Oncol. 2017 Apr 47(4):306-312.
• Mizukami T,Yokoyama A,Yokoyama T,et al : Screening by Total Colonoscopy Following Fecal Immunochemical Tests and Determinants of Colorectal Neoplasia in Japanese Men With Alcohol Dependence. Alcohol Alcohol. 2017 Mar 9;52(2):131-137.
• Yokoyama A,Yokoyama T,Mizukami T,et al. : Platelet Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men. Alcohol Clin Exp Res. 2017 41(1):171-178.

2016年

• Yokoyama A,Kamada Y,Imazeki H,et al. : Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men. Alcohol Clin Exp Res. 2016 40(6):1241-50.
• Yokoyama A,Brooks PJ,Yokoyama T,et al. : Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men. Alcohol Clin Exp Res. 2016 40(3):507-17.
• Yokoyama A,Yokoyama T,Mizukami T,et al. : Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men. Alcohol Alcohol. 2016 51(3):268-74.

2015年

• Yokoyama A,Yokoyama T,Matsui T,et al. : Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men. PLoS One. 2015 Aug 10(8):e0133460.
• 横山顕、松下幸生、遠山朋海ほか : 認知行動療法後の再発アルコール依存症患者に対する再飲酒予防トレーニング －Coping Skills TrainingとCue Exposure Treatmentと手紙療法－. 日本アルコール・薬物医学会雑誌 2015 50(2):88-103

2014年

• Yokoyama A,Yokoyama T,Brooks PJ,et al. : Macrocytosis,macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men. Alcohol Clin Exp Res. 2014 May;38(5):1237-46.
• 横山顕、水上健、中山秀紀ほか : 禁煙治療プログラムを導入したアルコール依存症の入院治療とその治療成績. 日本アルコール・薬物医学会雑誌 2014 49(6):381-90.

2013年

• Yokoyama A,Mizukami T,Matsui T,et al. : Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men. Alcohol Clin Exp Res. 2013 37(8):1391-401.
• Yokoyama A,Yokoyama T,Matsui T,et al. : Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men. Alcohol Clin Exp Res. 2013 37(7):1123-32.
• Yokoyama A,Yokoyama T,Matsui T,et al. : Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism.  Alcohol Alcohol. 2013 Mar-Apr;48(2):146-52

2011年

• Yokoyama A,Omori T,Tokoyama T. : Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and Screening for Cancer in the upper aerodigestive tract in East Asians. Keio J Med 59; 115-130, 2011.
• Aida J,Yokoyama A,Izumiyama N,Nakamura K,Ishikawa N,Poon SS,Fujiwara M,Sawabe M,Matsuura M,Tomio A,Takubo K. : Alcoholics show reduced telomere length in the oesophagus. J Pathol 223; 410-416, 2011.

2010年

• Yokoyama A,Tsustsumi E,Imazeki H,Suwa Y,Nakamura C,Yokoyama T. : Polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men. Alcohol Clin Exp Res 34; 1246-1256, 2010
• Yang SJ,Yokoyama A,Yokoyama T,Huang YC,Wu SY,Shao Y,Niu J,Wang J,Lui Y,Zhou XQ,Yang CX. : Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: A meta-analysis. World J Gastroenterol 16; 4210-4220, 2010
• Yokoyama A,Yokoyama T,Omori T. : Past and current tendency for facial flushing after a small dose of alcohol is a marker for increased risk of upper aerodigestive tract cancer. Cancer Sci 2497-2498, 2010

2009年

• Yokoyama A,Kumagai Y,Yokoyama T,Omori T,Kato H,Igaki H,Tsujinaka T,Muto M,Yokoyama M,Watanabe H. : Health risk appraisal models for mass screeningfor esophageal and pharyngeal cancer: an endoscopic follow-up study of cancer-free Japanese men. Cancer Epidemiol Biomarkers Prev 18: 651-655, 2009
• Boccia S,Hashibe M,Galli P,De Feo E,Asakage T,Hashimoto T,Hiraki A,Katoh T,Nomura T,Yokoyama A,van Duijn CM,Ricciardi G,Boffetta P. Aldehyde : dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendlian randomization approach. Cancer Epidemiol Biomarkers Prev 18: 248-254, 2009
• Brooks PJ,Enoch MA,Doldman D,Li TK,Yokoyama A. : The alcohol flushing response : an unrecognized risk factor of esophageal cancer from alcohol consumption. PLoS Med 6:e50, 258-263, 2009
• Yokoyama A,Omori T,Yokoyama T,Kawakubo H,Mori S,Matsui T,Maruyama K. : Chronic atrophic gastritis and metachrnous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma. Alcohol Clin Exp Res 33: 898-905, 2009

2008年

• Yokoyama A,Tsutsumi E,Imazeki H,Suwa Y,Nakamura C,Mizukami T,Yokoyama T. : Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. Alcohol Clin Exp Res 32: 1607-1614, 2008
• Yokoyama A,Omori T,Yokoyama T,Sato Y,Kawakubo H,Maruyama K. : Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: A long-term endoscopic follow-up study. Cancer Sci 99: 1164-1171, 2008
• Yokoyama T,Yokoyama A,Kumagai Y,Omori T,Kato H,Igaki H,Tsujinaka T,Muto M,Yokoyama M,Watanabe H. : Health Risk Appraisal Models for Mass Screening of Esophageal Cancer in Japanese Men. Cancer Epidemiol Biomarkers Prev 17: 2846-2854, 2008
• Shimizu Y,Omori T,Yokoyama A,Yoshida T,Hirota J,Ono Y,Yamamoto J,Kato M,Asaka M. : Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine staining: high-grade intra-epithelial neoplasia turns pink within a few minutes. J Gastroenterol Hepatol 23: 546-550, 2008

2007年

• Yokoyama A,Omori T,Tanaka Y,Yokoyama T,Sugiura H,Mizukami T,Matsushita S,Higuchi S,Maruyama K,Ishii H,Hibi T. : p53 protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma. Cancer Lett 247: 243-252, 2007
• Yokoyama A,Tsutsumi E,Imazeki H,Suwa Y,Nakamura C,Yokoyama T. : Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. Int J Cancer 121: 1047-1054, 2007
• Yokoyama A,Yokoyama T,Omori T,Matsushita S,Mizukami T,Takahashi H,Higuchi S,Maruyama K,Ishii H,Hibi T. : Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis, and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men. J Gastroenterol Hepatol 22: 210-217, 2007
• Asakage T,Yokoyama A,Haneda T,Yamazaki M,Muto M,Yokoyama T,Kato H,Igaki H,Tsujinaka T,Kumagai Y,Yokoyama M,Omori T,Watanabe H. : Genetic polymorphisms of alcohol and aldehyde dehydrogenases and drinking, smoking, and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. Carcinogenesis 28: 865-874, 2007